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"I'm optimistic there could be a role for this compound in preventing the increased toxicity we face with aging, as our abilities to deal with toxins decline," Hagen said

Diabetes Obes Metab (2021) 23(9):21946

Findings published in a preprint from a phase I clinical trial on the GLP1glucagon receptor co-agonist NN1177 in adults with overweight or obesity have raised problems with deterioration of glucose tolerance and other safety concerns, despite inducing weight loss, which illustrates the difficulties in getting the agonist balance right during the preclinical development of co-agonist therapies 6,7

At the same time, experts remind us that weight-loss (bariatric) surgery remains the most proven and long-lasting solution, especially for people with severe obesity

Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells