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Bone fractures : Clinical trial data suggest a possible increased risk of bone fractures with canagliflozin, particularly in the first year of treatment
Contraindications Absolute contraindications: Personal or family history of medullary thyroid carcinoma
Other At-Risk Groups GLP-1 medications are generally not suitable for individuals with severe gastrointestinal disorders like gastroparesis, those with type 1 diabetes (as these drugs are approved only for type 2 diabetes and obesity), and people with a history of suicidal thoughts, active eating disorders, or heavy alcohol use
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