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Let's address them with clinical evidence

Compared with enzymatically cleavable linkers, acid labile linkers provide greater structural control through functional group modifications and steric adjustments, offering wider optimization potential for ADC development

Oxytocin receptor binding site density was found to be significantly elevated in the anterior cingulate cortex of MIA male mice compared to normal C57BL/6J mice

We found all three water-soluble CSD subregions (as well as water-soluble full-length CSD) improve skin phenotype and reduce epidermal thickness in IMQ-treated mice

doi: 10.1210/clinem/dgaa327 31 NovikoffAOBrienSLBerneckerMGrandlGKleinertMKnerrPJet al