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Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

Phase 3 results reported through May 2026 show retatrutide produced mean weight loss of up to 28.3% at 80 weeks and 30.3% at 104 weeks in non-diabetic populations, with gastrointestinal adverse events the most common reported safety signal

Avoid repeated freeze-thaw cycles, as this can degrade the peptides

B12 is essential for metabolic processes that convert food into energy

Novo Nordisks patents on semaglutide extend through 2032, allowing monopoly pricing without competition