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In particular, metabolites related to choline metabolism including phosphorylcholine (FC = 0.07, p = 1.22 10 -4 ), glycerol-3-phosphate (FC = 0.07, p = 4.13 10 -4 ), choline (FC = 0.09, p = 1.15 10 -3 ), phosphoethanolamine (FC = 0.11, p = 4.08 10 -5 ), glycerophosphocholine (FC = 0.13, p = 2.88 10 -4 ), and ethanolamine (FC = 0.39, p = 1.76 10 -4 ) were significantly decreased in biofilm
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The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis
Even so, early clinical data have drawn significant attention from researchers and clinicians