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On May 1, 2025, Eli Lilly announced that it withdrew its FDA application for Zepbound (tirzepatide) for the treatment of HFpEF in patients with obesity, stating that the FDA requires an additional confirmatory trial to support the application

Volcano plot visualization of GLP-1MK-801 relative to vehicle revealed transcripts associated with glutamatergic signalling, such as Grin2a , Grin2b , Shisa6 and Slc17a7 among the most differentially upregulated genes (Fig

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