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The placebo group saw only a 2.4% mean decrease in weight.A second study found that when GLP-1 is combined with a low-calorie diet and behavioral therapy, it results in an even more significant amount of weight loss

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Huguenin GV, Oliveira GM, Moreira AS, SaintPierre TD, Gonalves RA, Pinheiro-Mulder AR, Teodoro AJ, Luiz RR, Rosa G, 2015