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CRL4s consists of a scaffold subunit CULLIN4 and a catalytic subunit RBX1 (RING box protein-1) or ROC1 (Regulator of CULLINS-1) that recruit E2 enzymes 1,6,7

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Increase to 0.5 mg Weekly After Initial Tolerance Develops Once the initial four weeks are completed and tolerance is established, the dose is increased to 0.5 mg weekly

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