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Farnesoid X receptor (FXR) agonist There are two generations of FXR agonists, First-generation is obeticholic acid (OCA) (INT-747) and Second-generation is cilofexor (GS-9674) and tropifexor
maximum therapeutic effect achieved Jumping to higher doses too quickly is the most common cause of GI discomfort
In most cases, safety incidents involve battery fire or burning caused by thermal runaway, while true explosions are rare and usually occur as a result of uncontrolled internal pressure
CJC without DAC lacks this linker, has a half-life of ~30 minutes and elicits physiological pulsatile GH peaks
Blood 88(10):595a, 1996
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