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no direct PubMed-indexed studies have measured cortisol levels following Semax administration Nasal Administration: Local irritation possible but typically mild Long-term Data: Decades of Russian clinical experience suggest good safety profile Selank Safety Profile: (PMID: 25176261, PMID: 28280289) Excellent Tolerability: Very few reported adverse events No Dependence Risk: Does not produce tolerance or withdrawalmajor advantage No Sedation: Unlike benzodiazepines, does not cause drowsiness or cognitive impairment No Muscle Relaxation: Anxiolytic effects without physical sedation Immunomodulatory Effects: May affect immune function

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