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Although GPX4 depletion alone failed to affect HSCs function in vivo , Vav1- Gpx4 knockout mice fed with a vitamin E-depleted diet exhibited a reduced number of HSCs and dysregulated hematopoiesis, mainly due to increased ferroptosis [22]
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F/Fo for MRP1 was displayed as a function of ligand concentration
Under these conditions, depending on the organism lactate and/or ethanol are produced from the pyruvate generated during glycolysis (fig
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