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Most patients require long-term or indefinite GLP-1 therapy to maintain benefits, as discontinuation typically results in weight regain and worsening metabolic parameters
The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism
exendin-based glucagon like peptide-1 receptor agonists: a retrospective study in patients with type 2 diabetes
The medications also influence reward pathways in your brain, making high-calorie foods less appealing
Cardiovascular safety during and after use of phentermine and topiramate
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