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Whitby PW, VanWagoner TM, Springer JM, Morton DJ, Seale TW, Stull TL

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The theory of the origin of sleep which has gained the widest credence is the one that attributes it to anemia of the brain The idea behind this supposition has been that, as the day draws to an end, the circulatory mechanism becomes fatigued, the vasomotor center exhausted, the tone of the blood vessels deficient, and the energy of the heart diminished, and thus is the circulation to the cerebral arteries lessened. NATURE, May 5th, 1898

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While exercise naturally enhances glucose uptake in muscles, creating complementary effects with metformin, there's no universal rule requiring you to adjust medication timing specifically for workouts