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On the other hand, another study found that 3-month treatment with NR in a PD mouse model resulted in increased NMN and NAD + metabolism marker NAAD but did not increase NAD + levels 287

As several studies demonstrated that estrogen could inhibit the activity of GSK3 53,54,55 , we hypothesized that higher levels of estrogen in female mice suppress GSK3 activity, which would in turn prevent GSK3-dependent Nrf2 degradation

The researchers posited that this was due to the increased expression of BDNF in the brains of the rats exposed to Selank [13]

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Prasad SB, Shinde A, Srinivasrao DA, Famta P, Shah S, Kolipaka T et al (2025) Metal-organic frameworks as therapeutic chameleons: revolutionizing the cancer therapy employing novel nanoarchitectonics