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The gut absorbs only 6001,000 ml of fluid per hour at best too slow when dehydration is severe and symptoms are escalating

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But here is the catch that matters for HRT users: these medications significantly slow gastric emptying

Its natural role is to coordinate the body's response to a meal: stimulating insulin secretion, suppressing glucagon, slowing the rate at which the stomach empties its contents into the small intestine, and signaling to the brain that energy has arrived and appetite can be reduced

Standard titration spans 46 weeks from initiation to therapeutic dose