Because tirzepatide carries a boxed warning about a rare thyroid tumor observed in animals, it should not be used by anyone with a personal or family history of medullary thyroid cancer or MEN 2. Prescription only
FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy
Overweight and obesity management prescribing orlistat, liraglutide and semaglutide (NG246)
Clinical response: Reach out to patients, work to address barriers, and provide motivational support or technical assistance
GLP-1 AND GIP Given the extensive clinical experience with GLP-1 RAs and the established safety profile in cardiovascular disease settings, peptide multi-agonists have been developed to target multihormonal peptide-secreting enteroendocrine cells.8 Due to their glucose-lowering functions, the combination of GLP-1 and GIP hormones is one of the most attractive strategies for treating T2DM.8, 9 GLP-1 was first identified as a cleavage product of preproglucagon generated by L cells in the small intestine and functions to increase postprandial insulin production and lower blood glucose.10, 11, 12, 13 Since its discovery, efforts have focused on extending GLP-1 agonist activity through structural changes.14 Liraglutide and semaglutide, two long-acting GLP-1 RAs, have been authorized for the treatment of T2DM and obesity