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Pro-oxidant shift in Glutathione redox state during aging
The long half-life is achieved through fatty acid conjugation, similar in strategy to semaglutide
Regarding ferroptosis regulation, GGT-activated extracellular GSH catabolism produces iron-derived ROS, inducing lipid peroxidation via NF-B pathway activation (112)
Viability was then assessed at 48 h post-treatment with a CCK-8 assay kit (Beyotime, Shanghai, China) as above
Vomiting, diarrhea, constipation, reflux-like discomfort, and abdominal cramping can also occur
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