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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG
Kovatchev BP, Renard E, Cobelli C, Zisser HC, Keith-Hynes P, Anderson SM,
Furthermore, in other disease models (such as A-induced nerve cell damage), highly expressed or activated VDAC1 has been clearly involved in ferroptosis, exacerbating cell death by inhibiting anti-ferroptosis pathways (such as GPX4, AMPK/mTOR, Wnt/-catenin) (149)
The ongoing attack results in liver cell death over time and leads to liver fibrosis
Gemfibrozil alleviates cognitive impairment by inhibiting ferroptosis of astrocytes via restoring the iron metabolism and promoting antioxidant capacity in type 2 diabetes
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