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Hartwell et al (104) observed that CD8+ tumor-infiltrating T cells, under hypoglycemic and hypoxic conditions, alter the metabolic profile of tumor cells from glycolysis to fatty acid catabolism, thereby sustaining the energy supply and stemness characteristics of tumor cells

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Potentially deleterious reactive oxygen species (ie, superoxides, peroxides, and hydroxyl radicals) are produced during the oxidation of fuels (oxidative phosphorylation) in mitochondria as byproducts of the utilization of molecular oxygen in the electron transport chain