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These conjugates exhibited markedly enhanced degradation of EGFRdel19 under hypoxic versus normoxic conditions, establishing the feasibility of hypoxia-triggered PROTAC activation

About 1 in 100 patients develops severe constipation requiring prescription laxatives, dose reduction, or discontinuation

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State availability confirmed on a case-by-case basis following intake review and administrative checks

Of these three compounds the half-cell redox potential based on the ratio of GSH to oxidized glutathione (GSSG) is postulated to be a reliable marker of the intracellular redox state (Schafer and Buettner, 2001)