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This observation holds implications for the design and therapeutic use of positive GLP-1R allosteric modulators
These medications work by mimicking the action of glucagon-like peptide-1, a naturally occurring hormone that regulates appetite and blood sugar levels
More importantly, when detailed cellular analyses were performed with electron microscopy (EM), exact same cellular problems were detected both in the UMNs of ALS patients with TDP-43 pathology and the CSMN of this mouse model of TDP-43 pathology 16
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