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relevance to humans not established, but contraindicated in those with MTC/MEN2 history
Higher doses tend to produce faster initial results, but the trajectory of weight loss usually follows a similar curve regardless of starting dose, with the most dramatic losses occurring in the first three to six months
Wegovy may be appropriate when: The hiatus hernia is small and causes minimal or no symptoms Reflux symptoms are well-controlled with lifestyle modifications or medication (such as proton pump inhibitors) The patient has significant obesity-related health risks that would benefit from weight loss The patient understands the potential for temporary worsening of reflux symptoms Close monitoring and follow-up can be arranged Greater caution or alternative approaches may be warranted when: The patient experiences severe, poorly controlled reflux symptoms There is a history of complications such as oesophagitis, Barrett's oesophagus, or oesophageal stricture [14] [15] The patient has difficulty swallowing (dysphagia) or experiences frequent regurgitation Previous trials of reflux medications have been ineffective The patient has other gastrointestinal conditions that might be exacerbated, particularly severe gastroparesis Your prescribing clinician will consider your complete medical history, current symptoms, previous treatments, and overall health status
Body weight is important since larger bodies might need higher doses
