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Conversely, semaglutide is more effective at supporting weight loss than liraglutide but is better tolerated, according to a recent randomised controlled trial

Also report yellowing skin, dark urine, or unexpected fatigue changes

doi:10.4158/EP12376.OR Wang S, Wu Y, Zuo Z, Zhao Y, Wang K

Practical Considerations: Sequencing, Dosing, and Provider Guidance Most providers continue metformin during semaglutide initiation, as metformin is typically first-line in type 2 diabetes and does not interfere with GLP-1 therapy