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It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]

To cope with oxidative stress, arthropods evolve antioxidant enzymes for removing excess ROS to maintain intracellular redox homeostasis and avoid oxidative damage

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