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Similar to transcriptomic results from genetic perturbation screens such as Perturb-seq 17 , we noticed that groups of genes whose proteins exist in complexes, or function within the same biological pathways, often produced the same phenotype across multiple infection parameters (Fig 1E)

Multi-omics analysis reveals the propagation mechanism of ferroptosis in acute kidney injury

Thus, current efforts are focused on preserving basal autophagy levels in podocytes, a goal achievable through the administration of antioxidant compounds such as berberine, mangiferin, notoginsenoside R1, and geniposide ( Excessive OS exerts a dual impact on the integrity of the glomerular filtration barrier, both inducing dysfunction and exacerbating proteinuria and renal decline

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