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It is expected that there would be a trans-opening of the epoxide ring for 2 , so the resulting epimers would differ in the relative configuration of the thioacetal bridge and the alcoholic group depending on the orientation of compounds 1 and 2 in the transition state
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This prolonged receptor engagement provides sustained appetite suppression throughout the dosing interval
But these will take years to get through proper testing and FDA approval
Machann J, Thamer C, Schnoedt B, Stefan N, Stumvoll M, Haring HU, et al
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