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Vitamin C Reaches much higher blood levels than oral vitamin C and concentrates in white blood cells, supporting normal phagocytosis and antioxidant defenses

Some protocols emphasize local approaches near an injury site, while others emphasize systemic support

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Evidence that the enzymes themselves can be modified by redox-related processes such as S -nitrosylation (Romero-Puertas and Sandalio 2016), in addition to the transcriptional control of the genes encoding them, emphasizes the intricacy of the checks and balances operating to maintain redox homeostasis within the cellular environment

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