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GLUTATHIONE AS AN ANTIOXIDANT Oxygen radical stress occurs in all aerobic organisms as a result of aerobic metabolism, with intermediates such as superoxide and hydrogen peroxide that lead to further production of oxygen radicals, which can cause lipid peroxidation and disrupt metabolic processes

Growth Hormon IGF Res 35:2132 Olmos Y, Valle I, Borniquel S, Tierrez A, Soria E, Lamas S, Monsalve M (2009) Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes

It is also involved in numerous biochemical reactions such as protein and DNA synthesis and enzymatic activation, affecting virtually every system in the body, particularly the gastrointestinal, respiratory, nervous and immune systems

Proliferation (log 2 doublings, 5 days) of indicated UGDH-deficient cell lines expressing a sgRNA resistant UGDH cDNA or an empty vector under treatment with the indicated concentrations of ferrous ammonium citrate (FAC)