Medical societies, including the American Medical Association, have formally acknowledged that BMI is an imperfect measure of adiposity and metabolic health
This is not an issue of willpower or laziness
For weight management, tirzepatide (Zepbound) is indicated for adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity, and should be used in conjunction with a reduced-calorie diet and increased physical activity
Long-acting agonists include liraglutide, exenatide(Bydureon), albiglutide, dulaglutide, semaglutide, PEG-loxenatide and tirzepatide, which can maintain an appropriate agonist level in plasma throughout the 24 hours of the day
Most people regain weight and waste years in the cycle