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Heart Failure: In 2013, the SAVOR-TIMI trial reported a significantly increased risk of hospitalization for heart failure (HF) in patients taking saxagliptin

79 Current guidelines from the American Association of Clinical Endocrinologists recommend cautious use of GLP-1RAs in T2DM patients with a history of pancreatitis 80 (See Figures 2 and 3)

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