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Oncotarget (2017) 8(63):106693706

Individuals with certain MC4R genotypes may experience a weaker subjective appetite reduction from the same GLP-1 dose not because the medication isn't working pharmacologically, but because the downstream receptor response is genetically attenuated

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Some people may also develop severe gastrointestinal problems like bowel obstruction

Here, we employ a keratinocyte-based model and evaluated the skin irritation potential of copper compounds at cellular, genomic and proteomic levels