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Who Is a Good Candidate, and Who Should Avoid It Because the evidence and safety data are limited, candidacy is decided carefully and conservatively

In one case study, a woman with bipolar disorder felt an uncomfortable euphoria while taking semaglutide that resolved when she stopped the medication, suggesting that certain GLP-1s could impact mood in at least some individuals

Many participants in the trial reported gastrointestinal issues, such as nausea and vomiting, when taking the medication

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Keep in mind that a true B12 deficiency usually requires correction under a doctor's guidance sometimes with injections or high-dose supplements along with a maintenance dose to keep levels up afterward