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In NAFLD patients, Godex supplementation significantly reduced ALT and AST, increased mtDNA copy number, and decreased oxidative stress marker 8-oxo-7, 8-dihydro2'-deoxyguanosine (8-oxo-dG) ( L-carnitine also ameliorates oxidative stress by reducing ROS production ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) ( Beyond mitochondrial mechanisms, L-carnitine inhibits hepatocyte autophagy and apoptosis

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4 Department of Natural and Life Sciences, Long Island University, Brooklyn, NY, 11201, USA Correspondence: Dong H Kwon, Department of Natural and Life Sciences, Long Island University, 1 University Plaza, Brooklyn, NY, 11201, USA, Tel +1 718 780 4098, Fax +1 718 488 1465, Email [email protected] Abstract: Antibiotic resistance has spread globally among bacterial pathogens, becoming a significant challenge to public health