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For Aging and Longevity: As we age, glutathione levels naturally decline, contributing to increased oxidative stress and cellular damage

Older individuals may benefit more from supplementation and potentially tolerate higher doses well

CrossRef Effects of Cyclodextrin Curcumin Formulation on Ischemia-Reperfusion Injury in Porcine DCD Liver Transplantation Nicolas Meurisse, Tine Wylin, Veerle Heedfeld, Steffen Fieuws, Laurens Ceulemans, Ina Jochmans, Jacques Pirenne, Diethard Monbaliu Transplantation.2024

Interestingly, a few years ago it has been published that in flies missense mutations of the SLC25A39 homologue shawn results in accumulation of ROS as well as in mitochondrial dysfunction, synaptic defects, and neurodegeneration

Sartori, A