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FDA labels for Wegovy and Rybelsus warn of severe gastrointestinal adverse reactions but dont mention gastroenteritis

Across all GLP-1 medications, 12-month persistence (still taking the medication at one year) ranges from 38% to 56% depending on the study and population (Wilding et al., Diabetes Obes Metab 2023)

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

The decision marks a reversal for Caremark, which last summer became the only major pharmacy benefit manager to exclude Zepbound while continuing to cover rival Novo Nordisks Wegovy