change from baseline to week 52 in body weight (percentage change and kg change), BMI and waist circumference
In the primary Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023), retatrutide was studied across several dose levels, including: 1 mg (low dose) 4 mg (mid dose) 8 mg (higher dose) 12 mg (highest dose) These doses were administered as once-weekly subcutaneous injections
Once safely inside the mitochondrial matrix, a second enzyme, Carnitine Palmitoyltransferase II (CPT2), detaches the L-carnitine, freeing the fatty acid to undergo beta-oxidation
Consider Alternative Formulations In some cases, switching to non-oral formulations can bypass absorption challenges
For anyone making a decision today, the comparison is lopsided in one specific sense: tirzepatide is an option you can actually be prescribed, with an approved label, a regulated supply chain, and accumulating post-market safety data
