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14 , eabn3758 (2022)

This article separates published trial-grade data for each component from self-reported community data on the combined stack

Yao R, Gala KS, Ghusn W, Abboud DM, Wallace FK, Vargas EJ

Many patients do very well on these medications

Furthermore, the distribution of these developability metrics across design rounds (Supp Figure 1) demonstrated that the iterative optimization process maintained favorable biophysical properties, with round 4 candidates showing balanced pI values (68), high humanization scores (Hu 0.7), and consistently low risk scores for aggregation, viscosity, and non-specific binding