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Sixteen subjects developed rapidly progressive OA and required total joint replacements, prompting the FDA to request the suspension of the trials of tanezumab
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theyre byproducts of metabolism, immunity, and even exercise
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This endothelial protection aligns with the compounds nitric oxide pathway modulation and its ability to upregulate protective gene expression in vascular endothelial cells making it a potentially interesting subject for further cardiovascular research, particularly in the context of inflammation-driven vascular disease
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