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Large-scale clinical trials conducted prior to medication approval did not identify a significant signal for increased suicidal thoughts or behaviors

In the altered TCR repertoire or altered peptide model, the drug or its metabolite binds directly to the HLA complex or the TCR (respectively), altering either the peptide repertoire or the confirmation of TCR

Practical considerations such as injection frequency, needle size, and gastrointestinal tolerability may also influence individual patient selection

Currently undergoing Phase 2 trials, bimagrumab was originally developed by Novartis, but the drug has switched hands to Versanis, which was subsequently acquired by Eli Lilly

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