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Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

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The AGT rs699 and rs4762 polymorphisms have been found to be significantly associated with HAPE susceptibility in Chinese and Indian populations, respectively