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1 Introduction Globally, over 95% of diabetes cases are attributed to type 2 diabetes mellitus (T2DM), with subsequent cardiovascular complications emerging as the primary drivers of morbidity and mortality

Examples: Using Ozempic (semaglutide) for weight loss is off-label Zepbound is the FDA-approved version specifically labeled for obesity Why this matters: Off-label prescribing can be appropriate, but it may affect insurance coverage and requires careful follow-up and monitoring

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However, we found no associations between the changes in circulating SPARC and decorin levels and those in RM

This is a highly technical approach and often proprietary