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According to the Pan American Health Organization (PAHO), over 62 million people in the Americas live with diabetes, while awareness campaigns have expanded screening and treatment access across more than 35 countries, supporting increased adoption of advanced therapies including GLP-1 drugs
Still, results should be carefully generalized to cases of background kidney dysfunction or when using drugs with narrow therapeutic index
Introduction Diabetes, a serious chronic disease, is growing worldwide and is now one of the top ten leading causes of death worldwide ( SCs, as the main glial cells in the peripheral nervous system, possess regenerative properties of interest and have important roles in the nervous system in coordinating the gradual formation of peripheral nerves, ensuring neuronal survival, axonal support and myelination, and promoting neurodegeneration and regeneration ( Programmed cell death (PCD) is an active death process (e.g., apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis) that occurs after a cell receives a certain stimulus or signal in order to maintain the homeostasis of the internal environment ( SCs are an important link in the pathogenesis of DPN: the role of axons SCs encapsulate all axons in peripheral nerves and maintain the long-term functional integrity of axons (26, 27)
