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Hair follicles undergo continuous cycles of growth (anagen), regression (catagen), and rest (telogen) phases, with the duration and quality of anagen determining overall hair production and appearance

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We first validated that TYR could catalyze the in situ generation of VHL-recruiting PROTACs to efficiently degrade TYR both in vitro and in vivo for curtailing melanin synthesis to effectively treat skin hyperpigmentation

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