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FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

Low glutathione is commonly observed in wasting and negative nitrogen balance, as seen in cancer, HIV/AIDS, sepsis, trauma, burns, starvation and athletic overtraining

Low B12 doesnt directly cause weight gain, but chronic fatigue and slow metabolism from a deficiency may lead to reduced activity levels, contributing to weight gain over time

Given that the BP patients in the present study experienced psychosis, GSH may be involved in psychosis-associated pathophysiology that is shared by both SZ and BP

When it comes to slowing down the clock, Glutathione is in a league of its own