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Others may require dose escalation or maximal doses to experience an effect, and studies show that 20% of individuals are complete non-responders, meaning they do not experience any weight reduction despite maximal doses of the drug. With this in mind, the average experience with GLP-1s includes a gradual onset of benefits, says Dr
5 Accessibility remains a key consideration
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The most prevalent and consistent dose-limiting side effects observed across studies of FGF21 analogs in patients with metabolic disease are gastrointestinal (GI), including mild-to-moderate nausea and diarrhea (183, 245, 246, 298, 301)
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