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Targeting the incretin/glucagon system with agonists Figure 1: Schematic representation of the effects of multi-agonists targeting the receptors for GLP-1/Glucagon, GLP-1/GIP and GLP-1/GIP/Glucagon [28] In Part I of our blog we reported on dual receptor agonists targeting the incretin/glucagon system to treat obesity and type 2 diabetes mellitus with high efficacy
Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin
In animal studies, the offspring of vitamin D-deficient rodents show brain structural changes similar to those seen in schizophrenia, such as thinning of the cortex, enlargement of lateral ventricles, and increased brain size due to increased proliferation and reduced shedding of neurons (63)
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