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In receptor binding studies, the affinity of tirzepatide was comparable to that of native GIP for the GIP receptor and approximately fivefold weaker than that of native GLP-1 for the GLP-1 receptor [88]

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Scientific References Teichman SL, Neale AR, Lawrence B, Gagnon C, et al

161 Over a period of 24 weeks, all dosage groups of retatrutide showed significant improvements in reducing glycated hemoglobin (HbA1c) and body weight compared to the placebo group, especially in the higher dosage groups

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