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True anaphylaxis to B12 is extremely rare but has been documented in medical literature
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Glatter: In practice, many patients labeled non-responders to GLP-1 therapy are experiencing incomplete dosing, early discontinuation because of gastrointestinal side effects, insufficient treatment duration, or competing metabolic drivers such as severe insulin resistance, sleep disruption, sarcopenia, or medication-associated weight gain
BMJ Open 15, e095610
The Cardiovascular Biology of Glucagon-Like Peptide-1
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