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call 999 if accompanied by severe systemic illness) Signs of gallbladder disease : Right upper quadrant pain, jaundice, fever (contact GP urgently or NHS 111) Symptoms of thyroid tumours : Neck lump, hoarseness, difficulty swallowing (rare, but GLP-1 agonists carry a theoretical risk based on animal studies) [15] [21] Allergic reactions : Rash, swelling, difficulty breathing (call 999 for severe reactions with breathing difficulties) Acute kidney injury : Reduced urine output, swelling, confusion (contact GP urgently or NHS 111

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Rigid cyclic thiazolepeptide scaffold presents planar heterocycle that binds cyclophilin A active site with lownanomolar affinity, disrupting proteinprotein interactions

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