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Toward defining the preclinical stages of Alzheimers disease: recommendations from the national institute on aging-Alzheimers association workgroups on diagnostic guidelines for Alzheimers disease

While traditionally viewed as a symptom of low dopamine function, research suggests that some cases may involve dysregulated reward processing where the dopamine system responds inappropriately to rewards and reward cues

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For cagrilintide specifically, the coming years will determine whether its distinct mechanism can carve out a meaningful roleeither as a standalone therapy through the RENEW program or as part of combination approaches like CagriSema and potentially future pairings Other questions about cagrilintide Because cagrilintide is still in clinical development, many common questions relate to its availability, safety, and how it compares with existing medications

10.1111/nph.12304 25 ChisholmS